Amr Amin
Professor in Molecular Biology, UAE University, UAE
Title: Novel natural product may be a new hope in the fi ght against liver cancer
Biography
Biography: Amr Amin
Abstract
Th e multikinase inhibitor, sorafenib, remains for a decade now the fi rst and
only systemic therapy for the treatment of hepatocellular carcinoma (HCC).
Th us, a novel approach against HCC is essential for a better therapeutic
outcome. Th e aim of this study is to assess the chemopreventive action of
Saff ron’s main biomolecules against chemically-induced liver cancer in rats,
and to explore the mechanisms by which Saff ron’s biomolecules employ
their anti-tumor eff ects. We provide a network analysis of diff erentially
expressed genes in tissues of animals pre-treated with Saff ron’s biomolecules
in comparison to induced-HCC animal's tissue. To further support our
results, we assessed the in vitro eff ects of those natural products on cells
viability and cell cycle distribution. Network analysis was also conducted
and identifi ed NF-kB as a potential regulatory hub, and therefore, a
candidate therapeutic drug target.