Gastroenterology and Hepatology

Biography

Biography: Manoj Kumar Jha

Abstract

Introduction: We all know that H. pylori infection is major cause of
gastrointestinal disorders worldwide. And the developing country like Nepal
has very high prevalence of H. pylori infection. It plays major role in the
aetiopathogenesis of chronic gastritis, gastric ulcer disease, duodenal ulcer
disease, gastric carcinoma and MALT lymphoma.
Aim: This study is done in Western Part of Nepal to fi nd out the association
and prevalence of H. pylori associated gastritis by endoscopically obtained
mucosal biopsies in dyspeptic patients attending upper GI endoscopic
procedure.
Material & Method: We conducted this study in 500 symptomatic patients
(220 Female and 280 Male) attending gastro OPD over the period of 23
months (Jan 2016-Dec 2018). This study was conducted in one of the city
hospitals in Western Part of Nepal. We conducted this study in patients,
who had dyspeptic complains for more than one month and not relieved
properly with PPI treatment. Upper GI endoscopy was performed and
mucosal biopsies were taken for HPE and coordinated with department of
histopathology.
Result: It was not surprising for us that to get as much 270 patients having
positive H. pylori infection by Haemotoxylin and Eosin/Giemsa method in
the department of pathology. Prevalence was high in third and fourth decades
of life. Number of male patients was much higher than female.
Conclusion: In our study, prevalence of H. pylori was 54% in Western
Nepal, among symptomatic patients (with vague dyspeptic complains who
attended upper GI endoscopy). It also shows that upper GI endoscopy
guided biopsies and its evaluation by histopathological methods is of great
importance for diagnosis of H. pylori. It also shows that large scale studies
are required in remote areas of Nepal, where prevalence may be much higher
due to multiple factors (low socio-economic status, lack of education, food
habits, unhygienic drinking water, etc.)