Gastroenterology and Liver

Celiac Disease and Gluten-Related Disorders

Celiac disease and gluten-related disorders are increasingly recognized worldwide, affecting individuals across all age groups. This session explores the pathophysiology, diagnosis, management, and evolving research on celiac disease, non-celiac gluten sensitivity, and wheat allergy. Celiac disease is an autoimmune disorder triggered by gluten ingestion in genetically predisposed individuals, leading to intestinal damage and malabsorption. Diagnosis relies on serologic testing, HLA typing, and confirmatory intestinal biopsy, though newer diagnostic approaches like capsule endoscopy and point-of-care tests are emerging. Management primarily involves a lifelong gluten-free diet, but adherence challenges and hidden gluten sources complicate treatment. Researchers are developing non-dietary therapies, including enzyme therapy, tight junction modulators, and immunotherapies to improve patient quality of life. This session also examines the psychosocial impact of gluten-free living and the role of dietitians in patient education. The latest updates in diagnostic criteria, biomarkers, and gluten-free product regulation will be discussed to support better outcomes.